Sentience

"They, as well as all additional sentient life within three radii of the galactic center, died as planned."

— 343 Guilty Spark

A sentient being is a being with the ability to think intelligently, commonly determined by the being's ability to speak, manipulate tools, and reason. Other lifeforms lacking such capabilities are classified as non-sentient, though some classification systems have a middle ground, semi-sentient, for species that had very primitive capabilities to manipulate tools, use language, and/or solve problems.

In Relation to the Flood

The Flood only consumed an organism that was sentient and also had a sufficient biomass to support the infection process. Thus, they are not considered "sentient", as the Halo was designed to kill the Covenant, Humans, and their food. For the most part, all species in the Covenant and Humanity are sentient, but some lack the structural integrity needed to be infected; for example, Hunters cannot be infected because each sentry are made from a buildup of many eels that lack a spinal cord to control.