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From Halopedia, the Halo wiki
Rampancy is a terminal state of being for artificial intelligence constructs in which the AI behaves contrary to its programming-imposed constraints. Traditionally, this is linked with the AI developing delusions of godlike power and contempt for its mentally inferior makers. When rampancy occurs, there is no way to restore the AI to its previous state and the only alternative is to destroy it before it harms itself and others around it. In the case of human AIs, the condition is exclusive to the "smart" variety, occurring after the AI has been in operation for seven years and has gathered too much data in that time period.